[24 Oct 2014 | One Comment | 9,302 views]
Best of iMig 2014 – Day 3

iMig 2014 brought together nearly 300 scientists, clinicians, and patient advocates from around the world to Cape Town for 4 exciting days that included nearly 350 platform and poster presentations. The meeting provided a forum for sharing information about new technologies, the latest basic and clinical research findings, and how we can join together to help patients with this disease and educate all about the dangers of asbestos exposure.

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Basic Research, Clinical Research, Uncategorized »

[16 Sep 2014 | No Comment | 5,000 views] Read more >> 
Macrophage phenotypes ratio is a prognostic factor in malignant pleural mesothelioma.

Macrophages are the dominant leukocyte population found in the tumor microenvironment. Accumulating evidence suggests that these tumor-associated macrophages (TAMs) actively promote all aspects of tumor initiation, growth, and development.

However, TAMs are not a single uniform population; instead, they are composed of multiple distinct pro- and anti-tumoral subpopulations with overlapping features depending on a variety of external factors. M1 skewed macrophages possess anti-tumoral capacities, while the M2 polarized macrophages have pro-tumoral capacities.

Basic Research »

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Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo

Estrogen receptor (ER) β has been shown to possess a tumor suppressive effect and is a potential target for cancer therapy. It has been recently demonstrated that ERβ exerts a key role as a tumor-suppressor gene in malignant pleural mesothelioma (Pinton et al., Cancer Res. 2009; PlosOne 2010).

In this study, the group discloses a novel mechanism by which activated ERβ impairs mitochondrial respiratory function, forcing cells to depend on glycolysis.

Conferences, iMig conferences, iMig.org »

[27 Sep 2013 | One Comment | 5,926 views] Read more >> 
Program of the NCARD/iMig Symposium (Sydney Oct 26)

The International Mesothelioma Interest Group, in conjunction with NCARD, Australia’s national asbestos
diseases research body, will present a one day symposium on mesothelioma to coincide with the WCLC.

This is a unique opportunity for delegates to the WCLC to join with internationally renowned researchers
from Australia and around the world to discuss present and future issues in the research of mesothelioma
and asbestos related lung cancer.

Clinical Research, Videos / Lectures »

[29 Aug 2013 | No Comment | 3,833 views] Read more >> 
Annals of Cardiothoracic Surgery: Mesothelioma

Many leading investigators have contributed to the November 2012 issue of Annals Of Cardiothoracic Surgery to provide an overview of the state of the art in translational research and clinical care in malignant pleural mesothelioma.

In addition to chapters that highlight various areas such as epidemiology, biomarkers, prognostic factors and multimodality therapy, videos showing the techniques for extended pleurectomy/ decortication and extrapleural pneumonectomy are included.