[2 Oct 2014 | No Comment | 148 views]
Germline Mutation of Bap1 accelerates the development of asbestos-induced malignant mesothelioma

In the current study, Dr. Testa and his team at Fox Chase exposed mice with and without BAP1 mutations to asbestos, and they also followed a group of unexposed mutant mice to see if they developed any cancers.

By the end of the study, 73% of mutated mice exposed to asbestos had developed mesothelioma, compared to only 32% of exposed mice that did not carry any BAP1 mutation. In the mutant mice, the mesotheliomas appeared sooner, and were more aggressive, as well.

None of the unexposed mice that carried a BAP1 mutation developed mesothelioma after up to 87 weeks of follow-up, although one was diagnosed with a tumor of breast tissue origin.

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Basic Research, Clinical Research, Uncategorized »

[16 Sep 2014 | No Comment | 467 views] Read more >> 
Macrophage phenotypes ratio is a prognostic factor in malignant pleural mesothelioma.

Macrophages are the dominant leukocyte population found in the tumor microenvironment. Accumulating evidence suggests that these tumor-associated macrophages (TAMs) actively promote all aspects of tumor initiation, growth, and development.

However, TAMs are not a single uniform population; instead, they are composed of multiple distinct pro- and anti-tumoral subpopulations with overlapping features depending on a variety of external factors. M1 skewed macrophages possess anti-tumoral capacities, while the M2 polarized macrophages have pro-tumoral capacities.

Basic Research »

[1 Oct 2013 | No Comment | 3,794 views] Read more >> 
Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo

Estrogen receptor (ER) β has been shown to possess a tumor suppressive effect and is a potential target for cancer therapy. It has been recently demonstrated that ERβ exerts a key role as a tumor-suppressor gene in malignant pleural mesothelioma (Pinton et al., Cancer Res. 2009; PlosOne 2010).

In this study, the group discloses a novel mechanism by which activated ERβ impairs mitochondrial respiratory function, forcing cells to depend on glycolysis.

Conferences, iMig conferences, iMig.org »

[27 Sep 2013 | One Comment | 2,159 views] Read more >> 
Program of the NCARD/iMig Symposium (Sydney Oct 26)

The International Mesothelioma Interest Group, in conjunction with NCARD, Australia’s national asbestos
diseases research body, will present a one day symposium on mesothelioma to coincide with the WCLC.

This is a unique opportunity for delegates to the WCLC to join with internationally renowned researchers
from Australia and around the world to discuss present and future issues in the research of mesothelioma
and asbestos related lung cancer.

Clinical Research, Videos / Lectures »

[29 Aug 2013 | No Comment | 2,738 views] Read more >> 
Annals of Cardiothoracic Surgery: Mesothelioma

Many leading investigators have contributed to the November 2012 issue of Annals Of Cardiothoracic Surgery to provide an overview of the state of the art in translational research and clinical care in malignant pleural mesothelioma.

In addition to chapters that highlight various areas such as epidemiology, biomarkers, prognostic factors and multimodality therapy, videos showing the techniques for extended pleurectomy/ decortication and extrapleural pneumonectomy are included.