Recent studies have indicated that tumor-specific immune responses may be activated in patients with malignant mesothelioma, suggesting that inhibition of the immunosuppressive receptor cytotoxic T-lymphocyte-associated protein 4 (CTLA4) may enhance antitumor T-cell activity.
Calabrò and colleagues performed an open-label, single-arm phase II trial to investigate the safety and efficacy of tremelimumab, a monoclonal antibody related to ipilimumab that targets CTLA4, in 29 patients with unresectable malignant melanoma who had previously received platinum-based therapy.
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Estrogen receptor (ER) β has been shown to possess a tumor suppressive effect and is a potential target for cancer therapy. It has been recently demonstrated that ERβ exerts a key role as a tumor-suppressor gene in malignant pleural mesothelioma (Pinton et al., Cancer Res. 2009; PlosOne 2010).
In this study, the group discloses a novel mechanism by which activated ERβ impairs mitochondrial respiratory function, forcing cells to depend on glycolysis.
The International Mesothelioma Interest Group, in conjunction with NCARD, Australia’s national asbestos
diseases research body, will present a one day symposium on mesothelioma to coincide with the WCLC.
This is a unique opportunity for delegates to the WCLC to join with internationally renowned researchers
from Australia and around the world to discuss present and future issues in the research of mesothelioma
and asbestos related lung cancer.
Many leading investigators have contributed to the November 2012 issue of Annals Of Cardiothoracic Surgery to provide an overview of the state of the art in translational research and clinical care in malignant pleural mesothelioma.
In addition to chapters that highlight various areas such as epidemiology, biomarkers, prognostic factors and multimodality therapy, videos showing the techniques for extended pleurectomy/ decortication and extrapleural pneumonectomy are included.
More details emerge on the dangers of carbon nanotubes.
The authors have reviewed recent literature on the evidence that fibrous carbon nanotubes can elicit effects similar to asbestos at a molecular and pathological level.
This topic is of extreme importance to avoid another asbestos disaster while developing these new microscopic tools in the industrial / medical setting.
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