Welcome to our new iMig website.
This website is designed to support, inform and provide a forum for iMig members, those who do research in mesothelioma and those who care for patients with mesothelioma. Mesothelioma is a global disease and we who study it are also spread around the globe.Therefore, the imig.org site is designed to provide a home and a research community for our international group.
In addition, we aim to present unbiased, authoritative information about mesothelioma for those who seek it.
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At the 10th Annual MARF meeting Gala Dinner on June 12th, V. Courtney Broaddus, M.D., Professor of Medicine at the University of San Francisco and Chief of the Pulmonary Division and Critical Care Medicine at San Francisco General Hospital, received a Pioneer Award for her achievements in the research field of mesothelioma and service to MARF.
In addition to her publications on asbestos- induced mechanisms of cell death in mesothelial cells, Courtney has developed a novel spheroid cell culture system to study signaling pathways of apoptosis resistance in mesothelioma cells and …
An article from the Collegium Ramazzini on the need for asbestos ban regulations worldwide.
The first call for a universal ban on asbestos by the Collegium Ramazzini was made in 1999. Still, asbestos is though still mined and used in several countries across the globe.
This newsletter provides an update on the topic.
Suggested by Dr Jim teWaterNaude MBChB, MPhil (MCH), FCPHM
The Nf2 gene is mutated in 40% of mesotheliomas and and disruption of the Nf2/Merlin signaling is key to Anton Berns’ murine mesothelioma model. The authors here propose that Merlin suppresses tumorigenesis by translocating to the nucleus and by inhibiting CRL4(DCAF1), an E3 ubiquitin ligase. This breakthrough finding opens up a new candidate drug target for the treatment of NF2 tumors – especially because many patients have gene mutations that affect this cell signaling pathway at various levels.
