Home » Archive

Articles in the Basic Research Category

Asbestos, Basic Research, Clinical Research, Conferences / Lectures, Featured, Opportunities »

[25 May 2010 | No Comment | 1,002 views]
iMig 2010 Young Investigator Awards

The IMIG Board of Directors is pleased to announce that 3 Young Investigator Awards will be given at the upcoming IMIG meeting in Kyoto.
The funding for these three awards has been donated in honor of 3 important advocacy organizations that work to ban asbestos:

BANJAN (Ban Asbestos Network Japan) Young Investigator Award ($2000)
ADAO (Asbestos Disease Awareness Organization) Young Investigator Award ($1500)
IBAS (International Ban Asbestos Secretariat) Young Investigator Award ($1500)

Awardees will be selected by the IMIG Board from submitted abstracts for the Kyoto meeting.

Submit your abstracts here by June 1st.

Basic Research »

[3 May 2010 | No Comment | 110 views]
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.

The Nf2 gene is mutated in 40% of mesotheliomas and and disruption of the Nf2/Merlin signaling is key to Anton Berns’ murine mesothelioma model. The authors here propose that Merlin suppresses tumorigenesis by translocating to the nucleus and by inhibiting CRL4(DCAF1), an E3 ubiquitin ligase. This breakthrough finding opens up a new candidate drug target for the treatment of NF2 tumors – especially because many patients have gene mutations that affect this cell signaling pathway at various levels.