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Articles in the Clinical Research Category

Clinical Research, Headline »

[26 Nov 2013 | No Comment | 3,170 views]
An Anti-CTLA4 antibody may be effective in malignant mesothelioma

Recent studies have indicated that tumor-specific immune responses may be activated in patients with malignant mesothelioma, suggesting that inhibition of the immunosuppressive receptor cytotoxic T-lymphocyte-associated protein 4 (CTLA4) may enhance antitumor T-cell activity.

Calabrò and colleagues performed an open-label, single-arm phase II trial to investigate the safety and efficacy of tremelimumab, a monoclonal antibody related to ipilimumab that targets CTLA4, in 29 patients with unresectable malignant melanoma who had previously received platinum-based therapy.

Clinical Research, Videos / Lectures »

[29 Aug 2013 | No Comment | 2,416 views]
Annals of Cardiothoracic Surgery: Mesothelioma

Many leading investigators have contributed to the November 2012 issue of Annals Of Cardiothoracic Surgery to provide an overview of the state of the art in translational research and clinical care in malignant pleural mesothelioma.

In addition to chapters that highlight various areas such as epidemiology, biomarkers, prognostic factors and multimodality therapy, videos showing the techniques for extended pleurectomy/ decortication and extrapleural pneumonectomy are included.

Basic Research, Clinical Research »

[10 May 2013 | One Comment | 16,508 views]
A new way of looking at cancer is on its way

The progression and evolution of cancer genomics is giving us unprecedented insight into malignancies. Most recently, a paper on acute myeloid leukemia and one on endometrial carcinoma, part of an ambitious project by the National Institutes of Health to scrutinize DNA aberrations in common cancers, have highlighted that cancer will increasingly be seen as a disease defined by its genetic fingerprint rather than by the organ where it originated.

Basic Research, Clinical Research »

[8 Apr 2013 | No Comment | 4,744 views]
Sequential Binary Gene-Ratio: a novel molecular diagnostic strategy

Though long considered the gold-standard for diagnosing cancer, customary pathological approaches are not always successful.

Here, De Rienzo and colleagues applied the bioinformatic technique of gene-expression ratio tests to develop and validate molecular signatures for the differential diagnosis of mesothelioma (MPM) as proof of principle of the applicability of this technique to cancer diagnosis.

Asbestos, Basic Research, Clinical Research »

[29 Nov 2012 | No Comment | 4,790 views]
Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool

Early detection of mesothelioma is key for chemo-efficiency. The authors conducted a multi-center case-control studies in serum from 117 mesothelioma cases and 142 asbestos-exposed control individuals. Biomarker discovery, verification, and validation were performed using the SOMAmer proteomic technology, which simultaneously measures over 1000 proteins in unfractionated biologic samples. Using univariate and multivariate approaches they discovered 64 candidate protein biomarkers, consisting of both inflammatory and proliferative proteins, processes strongly associated with asbestos-induced malignancy. The author further selected a pool of 13 candidate proteins (classifiers) for distinguishing mesotheliomas from controls. The ability of the classifiers …

Clinical Research, iMig conferences »

[4 Sep 2012 | 3 Comments | 5,964 views]
Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group

This publication represents an update to the iMig guidelines that were first published in 2009, following the iMig meeting held in Chicago (Oct. 2006). This update is meant to be a practical guide for pathologists and presents consensus views on diagnosis and the common pitfalls to be avoided.
 

Basic Research, Clinical Research »

[2 May 2012 | No Comment | 1,243 views]
MARF 2012 Grant Program – Call for Applications

The Mesothelioma Applied Research Foundation is calling for applications for its 2012 round of mesothelioma research grant funding. Continuing its efforts to stimulate translational research for the treatment of malignant mesothelioma, the Meso Foundation is again soliciting applications for funding of innovative projects that address issues for the treatment of the disease.

Clinical Research »

[26 Mar 2012 | 2 Comments | 3,863 views]
Serum mesothelin for diagnosing malignant pleural mesothelioma

Mesothelin is currently considered the best available serum biomarker for malignant pleural mesothelioma. To examine the reported diagnostic accuracy of mesothelin and evaluate its value for early diagnosis, the authors performed a meta-analysis on the individual patient data (IPD) of 16 diagnostic studies, representing a total of 4,491 individuals, including 1,026 patients with malignant pleural mesothelioma.
They found a significant heterogeneity in reported diagnostic accuracies of mesothelin (see Figure for sensitivity of mesothelin in different studies). Differences in study population can explain this heterogeneity, since the type of control group, mesothelioma …

Basic Research, Clinical Research »

[14 Mar 2012 | No Comment | 2,353 views]
TGF-beta signaling and defects in the NF2-Hippo pathway cooperate to promote mesothelioma growth

A recent publication by Sekido and colleagues has highlighted the connection between two relevant survival/growth pathways in mesothelioma, TGF-beta and NF2/Hippo.

TGF-beta may play important roles in the immune regulation of mesothelioma and in the production of extracellular matrix.
NF2 (neurofibromatosis type 2; Merlin) gene or downstream signaling molecules of the Hippo signaling cascade contain inactivating mutations in nearly 75% of MM cases.

Clinical Research »

[17 Oct 2011 | No Comment | 1,745 views]
Treatment of mesothelioma with gene-modified PA1STK cells and ganciclovir: a phase I study

This article presents the results in humans of the first intrapleural instillation of a genetically modified cell line carrying a thymidine kinase suicide gene in mesothelioma.  From prior work, these instilled cells are thought to adhere to the intrapleural tumor and to form gap junctions.  Then, a pro-drug, ganciclovir, is delivered intravenously, diffuses into the pleural space and is converted by the TK gene in the cells to a toxic drug, ganciclovir-triphosphate, which kills the instilled cells and neighboring tumor cells via a ‘bystander effect’.  The process may also induce …