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Articles tagged with: carboplatin

Basic Research »

[30 Jan 2012 | No Comment | 9,560 views]
BRCA1 is an essential mediator of vinorelbine induced apoptosis in mesothelioma

The BRCA1 (breast cancer gene 1) tumour suppressor gene has been reported as a potential predictive biomarker of response to chemotherapy to antimicrotubule agents including vinorelbine, vincristine, paclitaxel and docetaxel. High levels of BRCA1 mRNA expression have been linked to better response rates and improved progression-free survival.

The data presented here highlights that BRCA1-immunonegativity can effectively predict resistance to vinorelbine and microtubule-directed chemotherapy .

Clinical Research »

[4 Feb 2011 | No Comment | 4,143 views]
Thymidylate synthase and excision repair-cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed-carboplatin.

In this retrospective study by Italian and Dutch researchers, mesothelioma samples from 99 patients treated with carboplatin and pemetrexed were analysed for markers of clinical outcome.
A low level of protein expression of thymidylate synthase (TS), the major folate-dependent enzyme inhibited by pemetrexed, correlated with improved outcome: better disease control, longer progression free survival and longer overall survival. In contrast, the level of protein expression of ECRR1, an excision repair gene associated with platin resistance in some tumors, did not. This study is the first to show that …