Articles tagged with: p16(INK4A)
Basic Research »
Here is a paper by Deborah Altomare analyzing Ink4A and Arf role in mesothelioma pathogenesis.
p16(INK4A) and p14(ARF) are frequently co-deleted in human malignant mesothelioma and the authors here find that in vivo both CDKN2A/ARF gene products suppress asbestos carcinogenicity. Furthermore, while the inactivation of Arf appears to be crucial for mesothelioma pathogenesis, the inactivation of both p16(INK4A) and p19(ARF) cooperate to accelerate asbestos-induced tumorigenesis.