A recent publication by Sekido and colleagues has highlighted the connection between two relevant survival/growth pathways in mesothelioma, TGF-beta and NF2/Hippo.

TGF-beta may play important roles in the immune regulation of mesothelioma and in the production of extracellular matrix.
NF2 (neurofibromatosis type 2; Merlin) gene or downstream signaling molecules of the Hippo signaling cascade contain inactivating mutations in nearly 75% of MM cases.